(CNN) President Donald Trump criticized Sen. Lisa Murkowski on Twitter Wednesday after she voted against GOP-led efforts to dismantle Obamacare, making her the latest Republican to be publicly rebuked by Trump on the issue.

"Senator @lisamurkowski of the Great State of Alaska really let the Republicans, and our country, down yesterday. Too bad," he tweeted.

Murkowski and Sen. Susan Collins of Maine were the only two GOP senators to vote against a procedural vote backed by Senate Majority Leader Mitch McConnell Tuesday afternoon. They were also among the nine Republicans who voted Tuesday night against the Better Care Reconciliation Act, a version of the health care overhaul bill.

Murkowski responded to Trump Wednesday afternoon.

"My vote yesterday was from my heart for the people that I represent," Murkowski told CNN's Elizabeth Landers. "I'm going to continue working hard for Alaskans and focus on that."

Notably, Trump has not yet publicly criticized Collins on social media in the wake of Tuesday's vote.

But the President subtly warned Republicans that their political futures could be in jeopardy if they don't support his efforts.

"Any senator who votes against repeal and replace is telling America that they are fine with the Obamacare nightmare, and I predict they'll have a lot of problems," he said at a rally in Youngstown, Ohio, Tuesday night.